Resident Evil Resistanceis an entirely stand-aloneasymmetrical 4v1 multiplayer gamethat comes bundled with theResident Evil 3base game. The first notion to keep in mind here is thatResistanceis not canon, as Capcom has confirmed.
Given thatResident Evil Resistanceis not canon, many fans will hope Capcom releases future updates with new content, and some ofResident Evil’smost iconic villains could make great additions to this game.

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InResident Evil Resistance,the player who controls the villain actually takes control of a Mastermind, who sits at a terminal deploying traps, monsters, and other exploits before finally unleashing one particularly devastating monstrosity on the four players controlling Survivors attempting to escape. Currently, fourMastermind’s inResident Evil Resistanceand their deployed monstrosities have been revealed by Capcom inResident Evil Resistancefor players to control.

Daniel Fabron can unleash and take control of a Tyrant, Annette Birkin can deploy the G-Virus-infected Dr. William Birkin on players,Alex Weskerhas an Ivy and Plant 42-inspired monster known as the Yateveo, and Ozwell Spencer will unleash himself on players. Additional Masterminds and their deployed monster counterparts have been chosen which would make worthy additions to future updates or DLC forResident Evil Resistance.
Albert Wesker and Uroboros Albert Wesker
If there is one villain in theResident Evilseries fans would enjoy having inResistanceperhaps most, it would be none other thanResident Evil’siconic villain Albert Weskerhimself as he makes annihilating his foes seem smooth, casual and business as usual, with his bluetooth ear-piece and sunglasses intact as well. Given that Ozwell Spencer is already a Mastermind who can deploy himself into the battlefield confines against survivors, it would make sense for Albert Wesker to do the same, given his super-human abilities thanks to the Uroboros infection.
Nikolai Zinoviev and the Nemesis
Nikolai Sinoviev may not be one of the most iconic nor remembered villains in theResident Evilfranchise, but he was the secondary antagonist inResident Evil 3. Given thatResident Evil 3’sNemesisis one of the most frightening and iconic monsters in theResident Evilfranchise to date, so it seems that it would be most appropriate to include the Nemesis as a major threat to survivors inResistance.
Given that Nikolai was sent byUmbrella Corporationto Raccoon City to observe, gauge, and report on the performance of their Bio-Weaponry experiments, of which the Nemesis is its most valuable asset, it would make sense for Nikolai to be the Mastermind associated with a Nemesis inResistance.

Ramon Salazar and The Chainsaw Man
Ramon Salazar was one ofResident Evil 4’svillains, and though he was not the main villain, his role in governing the mountainous fortress and surrounding area would make him a great role for being a Mastermind. Furthermore, his eerie child-like appearance and wild taunting resonates the characteristics of a control freak.
UnleashingResident Evil 4’smasked chainsaw wielding Los Illuminados cultist, known simply as The Chainsaw Man, would add to Salazar’s frenzied chaos. The Chainsaw Man appears as if to be some sort of villain akin to theTexas Chainsaw Massacre,and the sound of the saw certainly does its job in getting under the players skin.

Alfred Ashford and Alexia Ashford
Alfred Ashford, similar to Ramon Salazar, carries an overly enthusiastic tone which comes off as both desperate and excited simultaneously. Mix that in with his dual personality in which he believes he is his sister Alexia and his role in governing Rockfort Island inResident Evil CODE: Veronica, and he would make a perfect Mastermind who is both a control freak and frighteningly crazed.
The T-Veronica infected Alexia Ashford would make perfect sense for Alfred to deploy. Though, in the actual game, Alfred was following her awakening from cryogenenic suspension, once again this can be overlooked given Capcom’s choosing to not make the series canon. If some semblance of chronology were maintained intact, then perhaps Alexia could be woken up early and temporarily as a means to deal with the survivors.

Dr. James Marcus and Lisa Trevor
Given Dr. James Marcus inResident Evil 0is on bad terms with Umbrella and only lives on thanks to the infection of hisT-Viruscarrying leeches, it would make some sense for him to use Lisa Trevor as his ultimate weapon in which to unleash on survivors. Lisa Trevor is perhaps one ofResident Evil’screepiest monsters but was also an unfortunate victim of Umbrella who endured many hideous deformities and genetic mutations which ultimately drove her mind mad, turning her into an especially hostile and terrorizing threat. In many ways, both Dr. Marcus and Lisa Trevor were victims of Umbrella’s hostilities, in different ways, and teaming them up would make for a worthy choice for Mastermind and monster inResistance.
Lucas Baker and Eveline
Lucas Baker sociopathic tendencies, sadistic mind games, and willingness to work for The Connections made him the only member ofResident Evil 7’sBaker familywho was not under control of Eveline. Given his mission in carrying out directives and tests for The Connections, it would make sense for him to be a Mastermind and deploy Eveline herself.
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Eveline and Jack Baker
Given that Eveline herself, by the nature ofthe mold experiment she is inResident Evil 7,is in many ways a Mastermind on a biological level, controlling members of the Baker family and having them carry out their directives would make her a suitable Mastermind as well, and not just a monstrosity to deploy. In consideration of the fact that Eveline is able to take control of a host which utilizes a video camera to send a video message to Ethan inResident Evil 7,it would seem perfectly viable that she has the smarts to utilize a computer system and take advantage of all the functions of a Mastermind character inResident Evil Resistance.
And while any one of the Baker family members can fulfill the creepiness and fright needed for the role of playing a threatening monstrosity, most fans would agree thatResident Evil 7’sJack Bakeris probably the most iconic and worthy of the bunch. Jack Baker resembles a stereotypical backwater serial killer, despite him being an actual victim when the storyline is.
Dr. Edward Kirk and Gigantasaurus
SinceResident Evil Resistancedoes not follow canon, the fun factor in turningDino Crisis’main antagonist, Dr. Edward Kirk, into a Mastermind would certainly be an interesting tribute to Capcom’s other classicsurvival horror franchiseDino Crisis.And nothing spells terror likeDino Crisis’giant-sized Gigantasaurus to be unleashed on players if the map design would allow for it. Otherwise, any one ofDino Crisis’reasonably sized dino meat eaters could suffice as a worthy addition toResistance.
Many of these characters and villains come from different time periods in the chronology ofResident Evil’suniverse. But given thatResident Evil Resistanceis geared for fun factor and likely experimentation, and since Capcom has confirmedResident Evil Resistancewill not follow canon, it would appear that all options are on the table.
Hopefully,Resident Evil Resistanceestablishes a worthy online community successfully, and Capcom continues to support the title with new updates and content for a long term, and new villains would help define it strongly.
Resident Evil Resistanceis bundled withResident Evil 3Remake and both will release for PS4, Xbox One and PC on May 28, 2025.